Rupal Gupta

My research interests broadly include investigating structure-function relationship of metalloproteins using biochemical and biophysical methodologies and, my research program aims to address the roles of metal ions in fundamental biological processes. With this broad aim in sight, my laboratory currently has two primary focus areas (i) developing methodologies to design new metalloenzymes capable of performing unique chemistry and (ii) evaluating inflammatory responses during infection in human bodies. Understanding how biomolecules execute their functionality at a fundamental and nanoscale level is critical for the development of engineered bio-inspired materials and targeted therapeutics. Our research endeavors, therefore, are well aligned with the broad goals and mission of the NanoBioNYC program. To further elaborate, we are involved in investigating metalloenzymes to elucidate fundamental principles that dictate reaction outcomes in biology. These efforts will provide fundamentals for the design of bio-inspired materials. Separately, we are working on extensive characterization of cellular signaling during infection and inflammation to construct a generalized model of human immune response. This work will support the development of therapeutics targeting modulation of innate inflammation induced upon pathogenic response in our bodies.