Mande Holford

The research in the Holford laboratory uses a “mollusks-to-medicine” strategy to discover novel peptides from venomous marine snails that could be used to manipulate cellular physiology pertaining to pain and cancer. Research projects in our lab applies inventive tools from chemistry and biology to: (1) investigate the evolution of venom in predatory marine snails, (2) discover disulfide-rich peptides from a venom source, (3) develop high-throughput methods for characterizing structure-function peptide interactions, and (4) deliver novel peptides to their site of action for therapeutic application.